The 1925 Hama uprising was one of the major events of the Great Syrian Revolt. It involved a rebel assault led by Fawzi al-Qawuqji against Mandatory French security installations in Hama and a subsequent uprising by residents sympathetic to the rebel cause. Heavy French bombardment of the city and the dispatch of reinforcements followed. The hostilities began on 4 October 1925 and negotiations between a delegation of Hama's leading families and the French authorities resulted in the rebels' withdrawal on 5 October.

In 1918, during World War I, the Ottoman Turks were driven out of Syria by the Allied Forces and their Hashemite Arab allies, after which the latter assumed authority over the country. In 1920 France gained control of Syria under the auspices of a mandate by the League of Nations, a move largely rejected by the general population. Syria was divided into six autonomous entities, including the State of Damascus and Jabal Druze State. Tensions between the French authorities and the leaders of Jabal al-Druze began to surface from 1922 and in the mid-summer of 1925, the Druze leader Sultan Pasha al-Atrash declared an uprising against the French Mandate after the imprisonment of three prominent Druze leaders who were invited to Damascus for talks with the authorities. After a number of significant military successes against the French Army, Syrian nationalists throughout the country were inspired to take up arms. One of those nationalists who was particularly impressed by the actions of al-Atrash's men was Fawzi al-Qawuqji, a veteran soldier from the Ottoman army who fought against the Italian occupation of Libya and later against the Allied forces in Syria. In 1925 he served as a cavalry commander for the French Syrian Legion.

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