The XXI edition of the Caribbean Series (Serie del Caribe) was played in 1978. It was held from February 4 through February 9 with the champions teams from the Dominican Republic, Águilas Cibaeñas; Mexico, Tomateros de Culiacán; Puerto Rico, Indios de Mayagüez and Venezuela, Leones del Caracas. The format consisted of 12 games, each team facing the other teams twice, and the games were played at Estadio Teodoro Mariscal in Mazatlán, México.