| Season | 1980–81 |
|---|---|
| Champions |
Juventus 19th title |
| Relegated |
Perugia Brescia Pistoiese |
| European Cup | Juventus |
| UEFA Cup |
Napoli Internazionale |
| Cup Winners' Cup | Roma |
| Matches played | 240 |
| Goals scored | 460 (1.92 per match) |
| Top goalscorer |
Roberto Pruzzo (18 goals) |
|
← 1979–80
1981–82 →
|
|
The 1980–81 Serie A season was won by Juventus F.C..