| 1981 Houston Astros | |
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| Major League affiliations | |
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| Location | |
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| Results | |
| Record | 61–49 (.555) |
| Divisional place | 3rd |
| Other information | |
| Owner(s) | John McMullen |
| General manager(s) | Al Rosen |
| Manager(s) | Bill Virdon |
| Local television | KRIV |
| Local radio |
KENR (Gene Elston, Dewayne Staats, Larry Dierker) |
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The Houston Astros' 1981 season was a season in American baseball. It involved the Houston Astros attempting to win the National League West.
On September 26, 1981, Nolan Ryan no-hit the Los Angeles Dodgers, 5-0, on national television. The 34-year-old right-hander became the first pitcher to throw five career no-hitters. It had been six years since Ryan's last no-hitter; he pitched for the California Angels for the last of four no-hitters.
Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in
Los Angeles Dodgers vs. Houston Astros
Los Angeles wins series, 3-2.
LEAGUE CHAMPIONS: Daytona Beach