1981 South American Championships – Singles
| Singles | |
|---|---|
| 1981 South American Championships | |
| 1980 Champion |
 José Luis Clerc
|
| Champion |
 Ivan Lendl
|
| Runner-up |
Guillermo Vilas
|
| Final score | 6–2, 6–2 |
José Luis Clerc was the defending champion but did not compete that year.
Ivan Lendl won in the final 6–2, 6–2 against Guillermo Vilas.
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.
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