Known a disappointing 2000–01 season, Massimo Moratti chose Héctor Cúper as the «coach of rebirth». Cúper managed to line-up a new team, buying players such as Toldo, Materazzi, Kallon and Ventola. Inter had a sprint-start, topping league and passing several challenges in Europe. 2001 closed with Giuseppe Prisco's death, vicechairman since 1962.

In second part of season Inter showed signs of exhaustion, unlike his opponents: 1–2 home k.o. by Atalanta was followed, on Thursday, from European elimination. Before the last league game, against Lazio, Inter was still at top with one point over Juventus and 2 over Roma. In first half nerazzurri scored twice, but both goals were equalized by Poborsky. During second 45' was instead Lazio - still in race for a UEFA Cup spot - to score two goals, winning eventually the match. Unbelievable defeat, also due to rivals' wins, made Inter fall to third place. A possible title was so changed in a Champions League playoff qualification. Lazio-Inter also marked Ronaldo's last appearance, with the striker captured in tears from cameras at stadium.

Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

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