The 2005–06 San Antonio Spurs season was the team's 39th overall season, the 33rd in San Antonio, and the 30th in the NBA. They began the season hoping to improve upon their 59–23 output from the previous season. They bested it by four games, finishing 63–19, and qualified for the playoffs for the ninth straight season. After defeating the Sacramento Kings by six games in the first games, the defending champions faced their in-state rival Dallas Mavericks. They were pushed to seven games and the Spurs ended up losing the deciding game of the series.

Tim Duncan and Tony Parker were selected to play in the 2006 NBA All-Star Game in Houston. This is Parker's first All-Star game appearance.

(1) San Antonio Spurs vs. (8) Sacramento Kings

Last Playoffs meeting: This is the first meeting between the Spurs and Kings.

(1) San Antonio Spurs vs. (4) Dallas Mavericks

Previous Playoffs meeting: 2003 Western Conference Finals (San Antonio won 4–2)

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