| Singles | |
|---|---|
| 2005 Family Circle Cup | |
| Champion |
|
| Runner-up |
|
| Final score | 7–5, 6–4 |
| Draw | 64 |
| Seeds | 16 |
Venus Williams was the defending champion, but lost in the third round to Tatiana Golovin.
Justine Henin-Hardenne won the title, defeating Elena Dementieva 7–5, 6–4 in the final.
The top eight seeds receive a bye into the second round.