2005 NASDAQ-100 Open – Women's Singles
| Women's Singles | |
|---|---|
| 2005 NASDAQ-100 Open | |
| Champion |
 Kim Clijsters
|
| Runner-up |
 Maria Sharapova
|
| Final score | 6–3, 7–5 |
Serena Williams was the defending champion, but she was defeated in the quarter-finals by her older sister Venus.
Unseeded Kim Clijsters of Belgium won the title with a straight sets 6–3, 7–5 victory over Russian second-seed Maria Sharapova.
All seeds receive a bye into the second round.
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