| Singles | |
|---|---|
| 2008 Copa Telmex | |
| Champion |  David Nalbandian | 
| Runner-up |  José Acasuso | 
| Final score | 3–6, 7–6(7–5), 6–4 | 
Juan Mónaco was the defending champion, but lost in the first round to Agustín Calleri.
David Nalbandian won in the final 3–6, 7–6(7–5), 6–4, against José Acasuso.