| Men's Singles | |
|---|---|
| 2008 Fifth Third Bank Tennis Championships | |
| Champion |
|
| Runner-up |
|
| Final score | 6–3, 6–3 |
John Isner was the defending champion, but decided not to compete this year.
Somdev Devvarman won the tournament, defeating Robert Kendrick in the final, 6–3, 6–3.