The 2010–11 season was ACF Fiorentina's 85th season in Italian football and their 73rd season in the first-tier, Serie A. This was also the sixth consecutive season for the club in the top-level division of the Italian football league system.

After five seasons at the helm of the Tuscan club, Cesare Prandelli was succeeded by Siniša Mihajlović, with the former taking the role as head coach of the Italian national team. For Fiorentina, this was also the first season from the last three that Fiorentina did not compete in a European competition, after finishing 11th the previous season.

Total spending: ~€17.1 million

Total income: ~€1.3 million

Last updated: 22 May 2011

Updated to games played on 22 May 2011.
Source: Lega Serie A
Rules for classification: 1st points; 2nd head-to-head points; 3rdhead-to-head goal difference; 4thhead-to-head goals scored; 5th goal difference; 6th goals scored
¹ As Internazionale the Champions League-qualifier won the 2010–11 Coppa Italia. Lazio and Roma will enter the 2011–12 UEFA Europa League play-off round as the 5th and 6th placed league team, while Palermo will enter the third qualification round as the cup runner-up.
² Bologna were deducted a total of 3 points: 1 point because of unpaid taxes, plus 2 points because of unpaid wages.
(C) = Champion; (R) = Relegated; (P) = Promoted; (E) = Eliminated; (O) = Play-off winner; (A) = Advances to a further round.
Only applicable when the season is not finished:
(Q) = Qualified to the phase of tournament indicated; (TQ) = Qualified to tournament, but not yet to the particular phase indicated; (RQ) = Qualified to the relegation tournament indicated; (DQ) = Disqualified from tournament.
Head-to-Head: used when head-to-head record is used to rank tied teams.

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