| Singles | |
|---|---|
| 2010 Family Circle Cup | |
| Champion |
|
| Runner-up |
|
| Final score | 6–0, 6–3 |
| Draw | 64 |
| Seeds | 16 |
Sabine Lisicki was the defending champion but chose not to compete due to a left ankle injury.
Samantha Stosur defeated Vera Zvonareva in the final (6–0, 6–3).
The top eight seeds receive a bye into the second round.