| Singles | |
|---|---|
| 2010 Heineken Open | |
| Champion |  John Isner | 
| Runner-up |  Arnaud Clément | 
| Final score | 6–3, 5–7, 7–6(7–2) | 
Juan Martín del Potro was the defending champion, but chose not to compete.
John Isner won in the final, 6–3, 5–7, 7–6(7–2), against Arnaud Clément.
The top four seeds receive a bye to the second round.