2010 Knoxville Challenger – Singles
| Singles | |
|---|---|
| 2010 Knoxville Challenger | |
| Champion |
 Kei Nishikori
|
| Runner-up |
 Robert Kendrick
|
| Final score | 6–1, 6–4 |
Taylor Dent was the defending champion, however he chose to not compete this year.
Kei Nishikori won this tournament. He defeated Robert Kendrick 6–1, 6–4 in the final.
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