| Men's Singles | |
|---|---|
| 2010 Kremlin Cup | |
| Champion |
|
| Runner-up |
|
| Final score | 3–6, 6–4, 6–3 |
Mikhail Youzhny was the defending champion, but withdrew due to a viral infection.
Viktor Troicki won this tournament. He defeated 4th seed Marcos Baghdatis 3–6, 6–4, 6–3 in the final.
The top four seeds received a bye into the second round.