| Singles | |
|---|---|
| 2010 Legg Mason Tennis Classic | |
| Champion |
|
| Runner-up |
|
| Final score | 6–2, 7–6(7–4) |
Juan Martín del Potro was the defending champion, but didn't participate due to a wrist injury.
David Nalbandian, ranked 117th, defeated Marcos Baghdatis 6–2, 7–6(7–4) in the final.
All seeds received a bye into the second round.