| Singles | |
|---|---|
| 2010 Regions Morgan Keegan Championships and the Cellular South Cup |
|
| Champion |
|
| Runner-up |
|
| Final score | 6–7(3–7), 7–6(7–5), 6–3 |
Andy Roddick was the defending champion, but lost in the quarterfinals to Sam Querrey.
Sam Querrey won in the final 6–7(3–7), 7–6(7–5), 6–3, against John Isner.