| 2010 Tennis Napoli Cup | |
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| Date | March 29 – April 4 |
| Edition | 14th |
| Location | Naples, Italy |
| Champions | |
| Singles | |
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| Doubles | |
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The 2010 Tennis Napoli Cup was a professional tennis tournament played on outdoor red clay courts. It was part of the 2010 ATP Challenger Tour. It took place in Naples, Italy between 29 March and 4 April 2010.
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following players received the lucky spots:
Rui Machado def.
Federico del Bonis, 6–4, 6–4
Dustin Brown /
Jesse Witten def.
Rohan Bopanna /
Aisam-ul-Haq Qureshi, 7–6(4), 7–5