2012 Challenger Ciudad de Guayaquil – Singles
| Singles | |
|---|---|
| 2012 Challenger Ciudad de Guayaquil | |
| Champion |
 Leonardo Mayer
|
| Runner-up |
 Paolo Lorenzi
|
| Final score | 6–2, 6–4 |
Matteo Viola was the defending champion but decided not to participate.
Leonardo Mayer won the title after defeating Paolo Lorenzi 6–2, 6–4 in the final.
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