| Men's Singles | |
|---|---|
| 2012 Fifth Third Bank Tennis Championships | |
| Champion |
|
| Runner-up |
|
| Final score | 5–7, 7–5, 6–1 |
Wayne Odesnik was the defending champion but decided not to participate.
Denis Kudla won the title, defeating Érik Chvojka 5–7, 7–5, 6–1 in the final.