| Singles | |
|---|---|
| 2012 Natomas Men's Professional Tennis Tournament | |
| Champion |
|
| Runner-up |
|
| Final score | 6–1, 1–6, 6–4 |
Ivo Karlović was the defending champion but decided not to participate.
James Blake won the title, defeating Mischa Zverev 6–1, 1–6, 6–4 in the final.