The 2012 Portland Timbers season was the 2nd season for the Portland Timbers in Major League Soccer (MLS), the top flight professional soccer league in the United States and Canada. The season ended with a 1-1 tie with San Jose on October 27, an MLS record of 8-10-16, and elimination from the MLS Cup at 8th place in the western converence and 17th in the overall MLS regular season standings. The Timbers won the 2012 Cascadia Cup with a record of 3-1-2 against Seattle and Vancouver, and lost to Cal FC in their opening round to be eliminated from the 2012 Lamar Hunt U.S. Open Cup. Including all previous teams in the area to bear the "Timbers" name, this is the 26th season in the history of the Portland Timbers franchise.

On July 9, Portland Timbers parted company with John Spencer. Gavin Wilkinson was then appointed as manager until the end of the season.