| Singles | |
|---|---|
| 2012 Regions Morgan Keegan Championships and the Cellular South Cup |
|
| Champion |
|
| Runner-up |
|
| Final score | 7–5, 7–6(7–4) |
Andy Roddick was the defending champion, but lost in the first round to Xavier Malisse. Jürgen Melzer defeated Milos Raonic in the final 7–5, 7–6(7–4).