| Singles | |
|---|---|
| 2012 San Luis Potosí Challenger | |
| Champion |
|
| Runner-up |
|
| Final score | 3–6, 6–3, 6–4 |
Santiago Giraldo was the defending champion but decided not to participate. Spanish Rubén Ramírez Hidalgo won the tournament with the score 3–6, 6–3, 6–4 in the final against Paolo Lorenzi.