2012 Conference USA football standings
	Conf				Overall
Team		W		L		W		L
East Division
UCF xy		7	–	1		10	–	4
East Carolina x		7	–	1		8	–	5
Marshall		4	–	4		5	–	7
Memphis		4	–	4		4	–	8
UAB		2	–	6		3	–	9
Southern Miss		0	–	8		0	–	12
West Division
Tulsa xy$		7	–	1		10	–	3
SMU		5	–	3		7	–	6
Rice		4	–	4		7	–	6
Houston		4	–	4		5	–	7
UTEP		2	–	6		3	–	9
Tulane		2	–	6		2	–	10
Championship: Tulsa 33, UCF 27
$ – Conference champion x – Division champion/co-champions y – Championship game participant Rankings from AP Poll

The 2012 Southern Miss Golden Eagles football team represented the University of Southern Mississippi in the 2012 NCAA Division I FBS football season as a member of the East Division of Conference USA. They were led by first-year head coach Ellis Johnson and played their home games at M. M. Roberts Stadium in Hattiesburg, Mississippi. The 2012 squad finished the season winless with a final record of 0–12 and after only one year at the helm, Johnson was fired.