The 2015–16 UEFA Champions League knockout phase began on 16 February and concluded on 28 May 2016 with the final at San Siro in Milan, Italy, to decide the champions of the 2015–16 UEFA Champions League. A total of 16 teams competed in the knockout phase.
Times up to 26 March 2016 (round of 16) were CET (UTC+1), thereafter (quarter-finals and beyond) times were CEST (UTC+2).
All draws were held at UEFA headquarters in Nyon, Switzerland.
The knockout phase involved the 16 teams which qualified as winners and runners-up of each of the eight groups in the group stage.
Each tie in the knockout phase, apart from the final, was played over two legs, with each team playing one leg at home. The team that scored more goals on aggregate over the two legs advanced to the next round. If the aggregate score was level, the away goals rule would be applied, i.e. the team that scored more goals away from home over the two legs advanced. If away goals were also equal, then thirty minutes of extra time would be played. The away goals rule would be again applied after extra time, i.e. if there were goals scored during extra time and the aggregate score was still level, the visiting team would advance by virtue of more away goals scored. If no goals were scored during extra time, the tie would be decided by penalty shoot-out. In the final, which was played as a single match, if scores were level at the end of normal time, extra time would be played, followed by penalty shoot-out if scores remained tied.