| Singles | |
|---|---|
| 2015 Memphis Open | |
| Champion |
|
| Runner-up |
|
| Final score | 6–4, 6–4 |
Kei Nishikori was the two-time defending champion and successfully defended his title, defeating Kevin Anderson 6–4, 6–4 in the final.
The top four seeds receive a bye into the second round.