2016 BB&T Atlanta Open – Singles
| Singles | |
|---|---|
| 2016 BB&T Atlanta Open | |
| Champion |
 Nick Kyrgios
|
| Runner-up |
 John Isner
|
| Final score | 7–6(7–3), 7–6(7–4) |
John Isner was the three-time defending champion, but lost in the final to Nick Kyrgios, 6–7(3–7), 6–7(4–7).
The top four seeds receive a bye into the second round.
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