| Men's Singles | |
|---|---|
| 2016 Brisbane International | |
| Champion |
|
| Runner-up |
|
| Final score | 6–4, 6–4 |
| Draw | 28 (4Q / 3WC) |
| Seeds | 8 |
Roger Federer was the defending champion, but lost in the final to Milos Raonic, 4–6, 4–6.
The top four seeds receive a bye into the second round.