| Men's Singles | |
|---|---|
| 2016 Claro Open Medellín | |
| Champion |
|
| Runner-up |
|
| Final score | 6–7(3–7), 7–5, 6–2 |
Paolo Lorenzi was the defending champion but chose not to defend his title.
Facundo Bagnis won the title after defeating Caio Zampieri 6–7(3–7), 7–5, 6–2 in the final.