2016 Memphis Open – Singles
| Singles | |
|---|---|
| 2016 Memphis Open | |
| Champion |
 Kei Nishikori
|
| Runner-up |
 Taylor Fritz
|
| Final score | 6–4, 6–4 |
Kei Nishikori was the three-time defending champion and successfully defended his title, defeating Taylor Fritz in the final, 6–4, 6–4.
The top four seeds receive a bye into the second round.
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