| Men's Singles | |
|---|---|
| 2016 Open Castilla y León | |
| Champion |
|
| Runner-up |
|
| Final score | 6–4, 3–6, 6–3 |
Evgeny Donskoy was the defending champion but chose not to defend his title.
Luca Vanni won the title after defeating Illya Marchenko 6–4, 3–6, 6–3 in the final.