| 2016 Open Engie Saint-Gaudens Midi-Pyrénées | |
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| Date | 9–15 May |
| Edition | 20th |
| Category | ITF Women's Circuit |
| Prize money | $50,000+H |
| Surface | Clay |
| Location | Saint-Gaudens, France |
| Champions | |
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The 2016 Open Engie Saint-Gaudens Midi-Pyrénées was a professional tennis tournament played on outdoor clay courts. It was the twentieth edition of the tournament and part of the 2016 ITF Women's Circuit, offering a total of $50,000+H in prize money. It took place in Saint-Gaudens, France, on 9–15 May 2016.
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry by a lucky loser spot:
The following player received entry by a protected ranking: