2016 São Paulo Challenger de Tênis – Singles
| Singles | |
|---|---|
| 2016 São Paulo Challenger de Tênis | |
| Champion |
 Gonzalo Lama
|
| Runner-up |
 Ernesto Escobedo
|
| Final score | 6–2, 6–2 |
Guido Pella was the defending champion but chose not to participate.
Gonzalo Lama won the title, defeating Ernesto Escobedo 6–2, 6–2 in the final.
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