2016 Samarkand Challenger – Singles
| Singles | |
|---|---|
| 2016 Samarkand Challenger | |
| Champion |
 Karen Khachanov
|
| Runner-up |
 Rubén Ramírez Hidalgo
|
| Final score | 6–1, 6–7(6–8), 6–1 |
Teymuraz Gabashvili was the defending champion, but chose not to defend his title.
Karen Khachanov won the title after defeating Rubén Ramírez Hidalgo 6–1, 6–7(6–8), 6–1 in the final.
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