2016 U.S. Men's Clay Court Championships – Singles
| Singles | |
|---|---|
| 2016 U.S. Men's Clay Court Championships | |
| Champion |
 Juan Mónaco
|
| Runner-up |
 Jack Sock
|
| Final score | 3–6, 6–3, 7–5 |
Jack Sock was the defending champion, but lost in the final to Juan Mónaco, 6–3, 3–6, 5–7.
The top four seeds receive a bye into the second round.
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