ACOT8

ACOT8
Identifiers
Aliases	ACOT8, HNAACTE, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE, NAP1, acyl-CoA thioesterase 8
External IDs	MGI: 2158201 HomoloGene: 3991 GeneCards: ACOT8
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.12 Start 45,841,721 bp End 45,857,406 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H3 Start 164,792,768 bp End 164,804,882 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • palmitoyl-CoA hydrolase activity • choloyl-CoA hydrolase activity • long-chain acyl-CoA hydrolase activity • carboxylic ester hydrolase activity • medium-chain acyl-CoA hydrolase activity • protein binding • receptor binding • hydrolase activity • CoA hydrolase activity • acyl-CoA hydrolase activity • acetyl-CoA hydrolase activity Cellular component • cytoplasm • peroxisome • peroxisomal matrix • mitochondrion Biological process • peroxisome organization • negative regulation of CD4 biosynthetic process • alpha-linolenic acid metabolic process • peroxisome fission • dicarboxylic acid catabolic process • fatty acid beta-oxidation using acyl-CoA oxidase • viral process • bile acid biosynthetic process • fatty acid catabolic process • acyl-CoA metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10005	170789
Ensembl	ENSG00000101473	ENSMUSG00000017307
UniProt	O14734	P58137
RefSeq (mRNA)	NM_005469 NM_183385 NM_183386	NM_133240
RefSeq (protein)	NP_005460	NP_573503
Location (UCSC)	Chr 20: 45.84 – 45.86 Mb	Chr 20: 164.79 – 164.8 Mb
PubMed search

10005

170789

ENSG00000101473

ENSMUSG00000017307

O14734

P58137

NM_005469
NM_183385
NM_183386

NM_133240

NP_005460

NP_573503

Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. Multiple transcript variants encoding several different isoforms have been found for this gene.

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