ACTN2

ACTN2

Protein ACTN2 PDB 1h8b.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1H8B, 1HCI, 1QUU, 4D1E, 5A37, 5A36, 5A38, 5A4B

Identifiers

ACTN2, CMD1AA, CMH23, actinin alpha 2

External IDs

MGI: 109192 HomoloGene: 31016 GeneCards: ACTN2

Gene ontology
Molecular function	• calcium ion binding • protein dimerization activity • protein homodimerization activity • ion channel binding • thyroid hormone receptor coactivator activity • protein domain specific binding • titin Z domain binding • LIM domain binding • titin binding • metal ion binding • cytoskeletal protein binding • integrin binding • actin filament binding • protein binding • ligand-dependent nuclear receptor transcription coactivator activity • identical protein binding • FATZ binding • actin binding • phosphatidylinositol-4,5-bisphosphate binding • structural constituent of muscle • Ras guanyl-nucleotide exchange factor activity
Cellular component	• cytoplasm • cytosol • pseudopodium • focal adhesion • filopodium • plasma membrane • sarcomere • dendritic spine • extracellular region • Z disc • cortical actin cytoskeleton • actin filament • extracellular exosome • cytoskeleton • platelet alpha granule lumen
Biological process	• positive regulation of cation channel activity • regulation of apoptotic process • muscle contraction • positive regulation of potassium ion transport • phospholipase C-activating angiotensin-activated signaling pathway • cardiac muscle cell development • regulation of membrane potential • platelet degranulation • actin filament uncapping • MAPK cascade • focal adhesion assembly • negative regulation of protein localization to cell surface • positive regulation of receptor activity • cell adhesion • negative regulation of potassium ion transmembrane transporter activity • negative regulation of potassium ion transport • regulation of nucleic acid-templated transcription • microspike assembly • positive regulation of endocytic recycling • muscle filament sliding • protein homotetramerization • sarcomere organization • establishment of protein localization to plasma membrane • positive regulation of potassium ion transmembrane transporter activity • positive regulation of GTPase activity
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE ACTN2 203863 at fs.png

PBB GE ACTN2 203861 s at fs.png

PBB GE ACTN2 203862 s at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


88


11472


ENSG00000077522


ENSMUSG00000052374


P35609


Q9JI91

RefSeq (mRNA)


NM_001103 NM_001278343 NM_001278344


NM_033268

RefSeq (protein)


NP_001094 NP_001265272 NP_001265273


NP_150371.4 NP_150371

Location (UCSC)

Chr 1: 236.69 – 236.76 Mb

Chr 13: 12.27 – 12.34 Mb

PubMed search

1H8B, 1HCI, 1QUU, 4D1E, 5A37, 5A36, 5A38, 5A4B

ENSG00000077522

ENSMUSG00000052374

NM_001103
NM_001278343
NM_001278344

NP_001094
NP_001265272
NP_001265273

NP_150371.4
NP_150371

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Wikipedia

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