ADAM19

ADAM19
Identifiers
Aliases	ADAM19, MADDAM, MLTNB, FKSG34, ADAM metallopeptidase domain 19
External IDs	MGI: 105377 HomoloGene: 74925 GeneCards: ADAM19
Gene ontology Molecular function • SH3 domain binding • peptidase activity • metalloendopeptidase activity • metallopeptidase activity • hydrolase activity • metal ion binding • protein binding Cellular component • integral component of membrane • Golgi apparatus • membrane • plasma membrane Biological process • heart development • membrane protein ectodomain proteolysis • proteolysis • extracellular matrix organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8728	11492
Ensembl	ENSG00000135074	ENSMUSG00000011256
UniProt	Q9H013	O35674
RefSeq (mRNA)	NM_023038 NM_033274	NM_001291890 NM_001291891 NM_009616 NM_001311209
RefSeq (protein)	NP_150377	NP_001278819 NP_001278820 NP_001298138 NP_033746
Location (UCSC)	Chr 5: 157.4 – 157.58 Mb	Chr 11: 46.06 – 46.15 Mb
PubMed search

8728

11492

ENSG00000135074

ENSMUSG00000011256

Q9H013

O35674

NM_023038
NM_033274

NM_001291890
NM_001291891
NM_009616
NM_001311209

NP_150377

NP_001278819
NP_001278820
NP_001298138
NP_033746

ADAM19 (A Disintegrin And Metalloproteinase 19, MADDAM, meltrin beta), is a human gene.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.

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Wikipedia