ADH1A

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1HSO, 1U3T

Identifiers

Aliases

ADH1A, ADH1, alcohol dehydrogenase 1A (class I), alpha polypeptide

External IDs

HomoloGene: 88335 GeneCards: ADH1A

Gene ontology
Molecular function	• oxidoreductase activity • zinc ion binding • protein binding • alcohol dehydrogenase (NAD) activity • metal ion binding • alcohol dehydrogenase activity, zinc-dependent • retinol dehydrogenase activity
Cellular component	• cytoplasm • nucleoplasm • cytosol • plasma membrane
Biological process	• drug metabolic process • alcohol metabolic process • oxidation-reduction process • ethanol oxidation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


124


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Ensembl


ENSG00000187758


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UniProt


P07327


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RefSeq (mRNA)


NM_000667


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RefSeq (protein)


NP_000658


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Location (UCSC)

Chr 4: 99.28 – 99.29 Mb

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PubMed search

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Alcohol dehydrogenase 1A is an enzyme that in humans is encoded by the ADH1A gene.

This gene encodes class I alcohol dehydrogenase, alpha subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. This gene is monomorphic and predominant in fetal and infant livers, whereas the genes encoding beta and gamma subunits are polymorphic and strongly expressed in adult livers.

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