ADH1B

ADH1B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1DEH, 1HDX, 1HDY, 1HDZ, 1HSZ, 1HTB, 1U3U, 1U3V, 3HUD
Identifiers
Aliases	ADH1B, ADH2, HEL-S-117, alcohol dehydrogenase 1B (class I), beta polypeptide
External IDs	HomoloGene: 133563 GeneCards: ADH1B
Genetically Related Diseases
alcohol abuse, esophageal cancer
Gene ontology Molecular function • oxidoreductase activity • zinc ion binding • alcohol dehydrogenase (NAD) activity • metal ion binding • alcohol dehydrogenase activity, zinc-dependent Cellular component • cytoplasm • nucleoplasm • cytosol • plasma membrane Biological process • oxidation-reduction process • ethanol oxidation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	125	n/a
Ensembl	ENSG00000196616	n/a
UniProt	P00325	n/a
RefSeq (mRNA)	NM_001286650 NM_000668	n/a
RefSeq (protein)	NP_000659 NP_001273579	n/a
Location (UCSC)	Chr 4: 99.3 – 99.32 Mb	n/a
PubMed search		n/a

1DEH, 1HDX, 1HDY, 1HDZ, 1HSZ, 1HTB, 1U3U, 1U3V, 3HUD

125

n/a

ENSG00000196616

n/a

P00325

n/a

NM_001286650
NM_000668

n/a

NP_000659
NP_001273579

n/a

Alcohol dehydrogenase 1B is an enzyme that in humans is encoded by the ADH1B gene.

The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.

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