ADH7

ADH7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AGN, 1D1S, 1D1T
Identifiers
Aliases	ADH7, ADH4, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
External IDs	MGI: 87926 HomoloGene: 37333 GeneCards: ADH7
Gene ontology Molecular function • aldehyde oxidase activity • zinc ion binding • metal ion binding • retinol dehydrogenase activity • ethanol binding • retinol binding • oxidoreductase activity • receptor antagonist activity • alcohol dehydrogenase (NAD) activity • alcohol dehydrogenase activity, zinc-dependent Cellular component • cytoplasm • cytosol • intracellular • extracellular region Biological process • ethanol catabolic process • response to bacterium • retinol metabolic process • retinoic acid metabolic process • fatty acid omega-oxidation • retinoid metabolic process • response to ethanol • oxidation-reduction process • ethanol oxidation • extracellular negative regulation of signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	131	11529
Ensembl	ENSG00000196344	ENSMUSG00000055301
UniProt	P40394	Q64437
RefSeq (mRNA)	NM_001166504 NM_000673	NM_009626
RefSeq (protein)	NP_000664 NP_001159976	NP_033756.2
Location (UCSC)	Chr 4: 99.41 – 99.44 Mb	Chr 3: 138.22 – 138.23 Mb
PubMed search

1AGN, 1D1S, 1D1T

131

11529

ENSG00000196344

ENSMUSG00000055301

P40394

Q64437

NM_001166504
NM_000673

NM_009626

NP_000664
NP_001159976

NP_033756.2

Alcohol dehydrogenase class 4 mu/sigma chain is an enzyme that in humans is encoded by the ADH7 gene.

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene makes it much more abundant in the stomach than the liver, thus it differs from the other known gene family members.

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