ALDH5

ALDH1B1
Identifiers
Aliases	ALDH1B1, ALDH5, ALDHX, aldehyde dehydrogenase 1 family member B1
External IDs	MGI: 1919785 HomoloGene: 115470 GeneCards: ALDH1B1
Gene ontology Molecular function • oxidoreductase activity • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor • aldehyde dehydrogenase (NAD) activity Cellular component • mitochondrial matrix • intracellular membrane-bounded organelle • mitochondrion • nucleoplasm Biological process • ethanol catabolic process • metabolic process • oxidation-reduction process • carbohydrate metabolic process • ethanol oxidation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	219	72535
Ensembl	ENSG00000137124	ENSMUSG00000035561
UniProt	P30837	Q9CZS1
RefSeq (mRNA)	NM_000692	NM_028270
RefSeq (protein)	NP_000683	NP_082546.1 NP_082546
Location (UCSC)	Chr 9: 38.39 – 38.4 Mb	Chr 4: 45.8 – 45.8 Mb
PubMed search

219

72535

ENSG00000137124

ENSMUSG00000035561

P30837

Q9CZS1

NM_000692

NM_028270

NP_000683

NP_082546.1
NP_082546

Aldehyde dehydrogenase X, mitochondrial is an enzyme that in humans is encoded by the ALDH1B1 gene.

This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems.

Model organisms have been used in the study of ALDH1B1 function. A conditional knockout mouse line called Aldh1b1^{tm2a(EUCOMM)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping

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