ALOXE3

ALOXE3
Identifiers
Aliases	ALOXE3, ARCI3, E-LOX, eLOX-3, eLOX3, arachidonate lipoxygenase 3
External IDs	MGI: 1345140 HomoloGene: 8013 GeneCards: ALOXE3
EC number	4.2.1.152
Gene ontology Molecular function • hepoxilin A3 synthase activity • iron ion binding • isomerase activity • dioxygenase activity • metal ion binding • protein binding • lyase activity • oxidoreductase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Cellular component • cytoplasm Biological process • linoleic acid metabolic process • establishment of skin barrier • lipid metabolic process • peroxisome proliferator activated receptor signaling pathway • ceramide biosynthetic process • fatty acid metabolic process • lipoxygenase pathway • hepoxilin biosynthetic process • sensory perception of pain • oxidation-reduction process • arachidonic acid metabolic process • fat cell differentiation • sphingolipid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	59344	23801
Ensembl	ENSG00000179148	ENSMUSG00000020892
UniProt	Q9BYJ1	Q9WV07
RefSeq (mRNA)	NM_021628 NM_001165960	NM_011786
RefSeq (protein)	NP_001159432 NP_067641	NP_035916.2 NP_035916
Location (UCSC)	Chr 17: 8.1 – 8.12 Mb	Chr 11: 69.13 – 69.15 Mb
PubMed search

59344

23801

ENSG00000179148

ENSMUSG00000020892

Q9BYJ1

Q9WV07

NM_021628
NM_001165960

NM_011786

NP_001159432
NP_067641

NP_035916.2
NP_035916

Epidermis-type lipoxygenase 3 (ALOXE3 or eLOX3) is a member of the lipoxygenase family of enzymes; in humans, it is encoded by the ALOXE3 gene. This gene is located on chromosome 17 at position 13.1 where it forms a cluster with two other lipoxygenases, ALOX12B and ALOX15B. Among the human lipoxygenases, ALOXE3 is most closely (54% identity) related in amino acid sequence to ALOX12B. ALOXE3, ALOX12B, and ALOX15B are often classified as epidermal lipoxygenases, in distinction to the other three human lipoxygenases (ALOX5, ALOX12, and ALOX15), because they were initially defined as being highly or even exclusively expressed and functioning in skin. The epidermis-type lipoxygenases are now regarded as a distinct subclass within the multigene family of mammalian lipoxygenases with mouse Aloxe3 (also termed e-Lox-3) being the ortholog to human ALOXE3, mouse Alox12b being the ortholog to human ALOX12B (MIM 603741), and mouse Alox8 being the ortholog to human ALOX15B (MIM 603697)[supplied by OMIM]. ALOX12B and ALOXE3 in humans, Alox12b and Aloxe3 in mice, and comparable orthologs in other in other species are proposed to act sequentially in a multistep metabolic pathway that forms products that are structurally critical for creating and maintaining the skin's water barrier function.

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Wikipedia