ANGPT4

ANGPT4
Identifiers
Aliases	ANGPT4, AGP4, ANG-3, ANG4, ANG3, angiopoietin 4
External IDs	MGI: 1336887 HomoloGene: 36302 GeneCards: ANGPT4
Gene ontology Molecular function • receptor tyrosine kinase binding • transmembrane receptor protein tyrosine kinase activator activity Cellular component • extracellular region • extracellular space Biological process • Notch signaling pathway • positive regulation of endothelial cell migration • negative regulation of angiogenesis • negative regulation of apoptotic process • negative regulation of blood vessel endothelial cell migration • cellular response to hypoxia • endothelial cell proliferation • angiogenesis • positive regulation of blood vessel endothelial cell migration • leukocyte migration • positive regulation of angiogenesis • positive regulation of peptidyl-tyrosine phosphorylation • activation of transmembrane receptor protein tyrosine kinase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51378	11602
Ensembl	ENSG00000101280	ENSMUSG00000027460
UniProt	Q9Y264	Q9WVH6
RefSeq (mRNA)	NM_015985 NM_001322809	NM_009641
RefSeq (protein)	NP_001309738 NP_057069	NP_033771.1 NP_033771
Location (UCSC)	Chr 20: 0.87 – 0.92 Mb	Chr 2: 151.91 – 151.95 Mb
PubMed search

51378

11602

ENSG00000101280

ENSMUSG00000027460

Q9Y264

Q9WVH6

NM_015985
NM_001322809

NM_009641

NP_001309738
NP_057069

NP_033771.1
NP_033771

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells.

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Wikipedia