ANKRD1

ANKRD1
Identifiers
Aliases	ANKRD1, ALRP, C-193, CARP, CVARP, MCARP, bA320F15.2, ankyrin repeat domain 1
External IDs	MGI: 1097717 HomoloGene: 8289 GeneCards: ANKRD1
Gene ontology Molecular function • DNA binding • RNA polymerase II transcription coactivator activity • R-SMAD binding • transcription corepressor activity • RNA polymerase II transcription factor binding • p53 binding • transcription factor binding • histone deacetylase binding • titin binding • protein binding Cellular component • cytoplasm • cytosol • I band • transcription factor complex • sarcomere • nucleoplasm • myofibril • nucleus • fibrillar center Biological process • response to muscle stretch • cellular response to transforming growth factor beta stimulus • regulation of transcription from RNA polymerase II promoter • cellular response to tumor necrosis factor • cellular response to organic cyclic compound • cardiac muscle tissue morphogenesis • negative regulation of transcription from RNA polymerase II promoter • cellular response to mechanical stimulus • cellular response to drug • cellular response to interleukin-1 • positive regulation of protein secretion • positive regulation of neuron projection development • positive regulation of apoptotic process • skeletal muscle cell differentiation • positive regulation of DNA damage response, signal transduction by p53 class mediator • cellular response to lipopolysaccharide • sarcomere organization • cellular response to hypoxia • negative regulation of DNA biosynthetic process • positive regulation of transcription from RNA polymerase II promoter • muscle cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27063	107765
Ensembl	ENSG00000148677	ENSMUSG00000024803
UniProt	Q15327	Q9CR42
RefSeq (mRNA)	NM_014391	NM_013468
RefSeq (protein)	NP_055206	NP_038496.2 NP_038496
Location (UCSC)	Chr 10: 90.91 – 90.92 Mb	Chr 19: 36.11 – 36.12 Mb
PubMed search

27063

107765

ENSG00000148677

ENSMUSG00000024803

Q15327

Q9CR42

NM_014391

NM_013468

NP_055206

NP_038496.2
NP_038496

CARP, also known as Cardiac adriamycin-responsive protein or Cardiac ankyrin repeat protein is a protein that in humans is encoded by the ANKRD1 gene. CARP is highly expressed in cardiac and skeletal muscle, and is a transcription factor involved in development and under conditions of stress. CARP has been implicated in several diseases, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and several skeletal muscle myopathies.

Human CARP is a 36.2kDa protein composed of 319 amino acids., though in cardiomyocytes, CARP can exist as multiple alternatively spliced forms. CARP contains five tandem ankyrin repeats. Studies have shown that CARP can homodimerize. Studies have also shown that CARP is N-terminally, post-translationally cleaved by calpain-3 in skeletal muscle, suggesting alternate bioactive forms of CARP exist. CARP has been localized to nuclei and Z-discs in animal and human myocytes, and at intercalated discs in human cells.

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Wikipedia