ARAF

ARAF

Protein ARAF PDB 1wxm.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WXM, 2MSE

Identifiers

ARAF, A-Raf proto-oncogene, serine/threonine kinase, A-RAF, ARAF1, PKS2, RAFA1

External IDs

MGI: 88065 HomoloGene: 1249 GeneCards: ARAF

Gene ontology
Molecular function	• transferase activity • protein kinase activity • nucleotide binding • signal transducer activity, downstream of receptor • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • MAP kinase kinase kinase activity • mitogen-activated protein kinase kinase binding
Cellular component	• mitochondrion • cytosol
Biological process	• intracellular signal transduction • regulation of TOR signaling • phosphorylation • negative regulation of apoptotic process • positive regulation of peptidyl-serine phosphorylation • MAPK cascade • protein phosphorylation • cellular protein modification process • regulation of proteasomal ubiquitin-dependent protein catabolic process • signal transduction • activation of MAPKK activity • multicellular organism development • negative regulation of signal transduction • cell differentiation • positive regulation of ERK1 and ERK2 cascade • immortalization of host cell
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE ARAF 201895 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


369


11836


ENSG00000078061


ENSMUSG00000001127


P10398 Q96II5


P04627

RefSeq (mRNA)


NM_001256196 NM_001256197 NM_001654


NM_001159645 NM_009703

RefSeq (protein)


NP_001243125 NP_001243126 NP_001645 NP_001243125.1


NP_001153117.1 NP_033833.1 NP_001153117 NP_033833

Location (UCSC)

Chr X: 47.56 – 47.57 Mb

Chr X: 20.8 – 20.86 Mb

PubMed search

ENSG00000078061

ENSMUSG00000001127

NM_001256196
NM_001256197
NM_001654

NM_001159645
NM_009703

NP_001243125
NP_001243126
NP_001645
NP_001243125.1

NP_001153117.1
NP_033833.1
NP_001153117
NP_033833

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Wikipedia

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