ARHGEF10

ARHGEF10
Identifiers
Aliases	ARHGEF10, GEF10, SNCV, Rho guanine nucleotide exchange factor 10
External IDs	MGI: 2444453 HomoloGene: 22827 GeneCards: ARHGEF10
Gene location (Human) Chr. Chromosome 8 (human) Band 8p23.3 Start 1,823,976 bp End 1,958,641 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A1.1 Start 14,911,663 bp End 15,001,085 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rho guanyl-nucleotide exchange factor activity • protein binding • kinesin binding • guanyl-nucleotide exchange factor activity Cellular component • cytosol • centrosome Biological process • mitotic spindle assembly • regulation of Rho protein signal transduction • positive regulation of stress fiber assembly • myelination in peripheral nervous system • centrosome duplication • activation of GTPase activity • regulation of molecular function Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9639	234094
Ensembl	ENSG00000104728 ENSG00000274726	ENSMUSG00000071176
UniProt	O15013	Q8C033
RefSeq (mRNA)	NM_001308152 NM_001308153 NM_014629	NM_001037736 NM_172751
RefSeq (protein)	NP_001295081 NP_001295082 NP_055444	NP_001032825 NP_766339
Location (UCSC)	Chr 8: 1.82 – 1.96 Mb	Chr 8: 14.91 – 15 Mb
PubMed search

9639

234094

ENSG00000104728
ENSG00000274726

ENSMUSG00000071176

O15013

Q8C033

NM_001308152
NM_001308153
NM_014629

NM_001037736
NM_172751

NP_001295081
NP_001295082
NP_055444

NP_001032825
NP_766339

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.

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Wikipedia