ARHGEF12

ARHGEF12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TXD, 1X86, 2OMJ, 2OS6
Identifiers
Aliases	ARHGEF12, LARG, PRO2792, Rho guanine nucleotide exchange factor 12
External IDs	MGI: 1916882 HomoloGene: 9088 GeneCards: ARHGEF12
Gene ontology Molecular function • protein binding • G-protein coupled receptor binding • GTPase activator activity • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • extracellular exosome • membrane Biological process • G-protein coupled receptor signaling pathway • positive regulation of GTPase activity • regulation of Rho protein signal transduction • intracellular signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23365	69632
Ensembl	ENSG00000196914	ENSMUSG00000059495
UniProt	Q9NZN5	Q8R4H2
RefSeq (mRNA)	NM_001198665 NM_001301084 NM_015313	NM_027144
RefSeq (protein)	NP_001185594 NP_001288013 NP_056128	NP_081420
Location (UCSC)	Chr 11: 120.34 – 120.49 Mb	Chr 9: 42.96 – 43.11 Mb
PubMed search

1TXD, 1X86, 2OMJ, 2OS6

23365

69632

ENSG00000196914

ENSMUSG00000059495

Q9NZN5

Q8R4H2

NM_001198665
NM_001301084
NM_015313

NM_027144

NP_001185594
NP_001288013
NP_056128

NP_081420

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptor . The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.

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